In this article, I distinguish two models of personal integrity. The first, wholeheartedness, regards harmonious unity of the self as psychologically healthy and volitional consistency as ethically ideal. I argue that it does so at the substantial cost of framing ambivalence and conflict as defects of character and action. To avoid these consequences, I propose an alternate ideal of humility that construes the self as multiple and precarious and celebrates experiences of loss and transformation through which learning, growth, innovation, and (...) dynamic relationship become possible. This ideal not only sustains prospects for integrity but is more suitable than wholeheartedness for recognizing practices of contestation, such as those involving potentially destabilizing encounters with difference that is common within pluralistic societies, as vital for rich, well-lived lives. (shrink)

The aim of this essay is to provide a philosophical discussion of Frederick Douglass's thought in relation to Christianity. I expand upon the work of Bill E. Lawson and Frank M. Kirkland—who both argue that there are Kantian features present in Douglass as it relates to his conception of the individual—by arguing that there are similarities between Douglass and Kant not only concerning the relationship between morality and Christianity, but also concerning the nature of the soul. Specifically, I try to (...) show that the moral weakness of slaveholding Christianity that Douglass attacked is found in the ecclesial formation of the slaveholding Christian church; it is a formation that begins with epistemology, but ignores ethics. I conclude, in part, that both Douglass and Kant reject a Cartesian psychological dualism in favor of a conception of the soul that is more attentive to one's moral development. (shrink)

This volume gathers together a series of widely-scattered articles concerned with the great tradition of Platonic scholarship - The golden Chain - from the time of Plato himself up into the period of Middle Platonism. The main emphasis, however, is on the first three centuries AD. The first articles address the question of what exactly was the nature of the Platonic school at various stages of its development and what kind of organization the Academy may have had. The following (...) ones present studies on figures from Speusippus in the Old Academy, through Philo of Alexandria and Origen (more honorary members of the Golden Chain), to Plotinus, Iamblichus and Proclus, and on some more general issues, such as the fall of the soul, which span much of the period. (shrink)

Based on the concept of shareholder primacy, many scholars have argued that it is more important for businesses to earn profits for their shareholders than to provide benefits to society at large. Corporate social responsibility is often regarded as an investment that comes at the expense of shareholders. In contrast, research analyzing the connections between the equity ownership structure of a company and its level of CSR engagement suggests that CSR offers benefits to shareholders that go beyond direct financial returns (...) from investments. This study provides a comprehensive review and systematic assessment of theoretical considerations and approaches regarding different forms of equity ownership and their relationships to CSR, and it discusses the relevant benefits and motivations of shareholders. The perceived value of these CSR benefits varies among different types of shareholders, as they assign unequal values to short-term financial or to rather long-term CSR benefits. Based on a literature sample of 146 publications, this review demonstrates central problems inherent in previous analyses. Given the ambiguous and partially contradictory findings of prior research, this study identifies potential moderating influences that help clarify empirical evidence. A contingency approach is suggested in future research, as this can help resolve the problem of contradictory empirical findings and theoretical arguments. (shrink)

This collection of articles explores a broad range of issues relating to the development of Platonism. The volume takes in such figures as John Scotus Eriugena and Salomon ibn Gabirol, while bearing witness to an understanding and appreciation of the last head of the Platonic Academy, Damascius. The volume begins with a study of an aspect of Plato himself, his distinctly ironic way of making use of the ancient concept of the golden age and the history of a notion (...) that he bequeathed to his successors, the idea that the philosopher should develop something of an art or science of erotics. The volume continues on to explore areas such as the philosophical stature of Plato's nephew and successor, Speusippus, the functioning of Platonic dialogues within the intellectual life of the school, issues and figures within middle Platonism - notably Philo of Alexandria and Plutarch - various aspects of Plotinus' thought, evidence from Porphyry and Iamblichus and different aspects of the philosophy of Proclus. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Knowing the EastPatti M. MarxsenKnowing the East. By Paul Claudel. Translated by James Lawler. Princeton, NJ: Princeton University Press, 2004. 136 pp.Fifty years after his death, Paul Claudel (1868–1955) is remembered for many things. Not only was he a major twentieth-century poet and playwright, he was an astute observer of Dutch, Spanish, and Japanese art. Not only was he the brother of sculptor Camille Claudel, he was a (...) diplomat who lived for nearly twenty years in Asia, including a stint as the French ambassador to Japan (1921–1927). When he was elected as a member of the Académie Française in 1946 at nearly 80 years of age he quipped, "For an academic, that is puberty." He died at 87, having lived large in two centuries and on three continents.Following an adolescence marked with indifference toward religion, Claudel experienced a profound conversion to Catholicism during a Christmas night service at Notre Dame Cathedral in Paris at the age of 18. With Christianity at the center of his universe and under the influence of Symbolist poets Rimbaud and Mallarmé, he developed a response to the world that was at once poetic and spiritual. Through his poetry, plays, and essays, he insisted on a fundamental unity between matter and spirit, a harmonious and vast universe into which the human mind could enter. And, at least for him, the point of entry was the portal of the Church. He struggled at times, but never lost sight of his faith. For all this, he is often credited with the revival of French Catholicism in the wake of WWI. After all, if Paul Claudel could take religion seriously and find meaning in it, pourquoi pas the rest of us?The facts of his extraordinary biography form a peculiar background to the recent translation by James Lawler of Claudel's collection of prose poems titled Knowing [End Page 229] the East. First published in 1946 as Connaissance de l'est, these sixty-one texts were written between 1895 and 1905 during Claudel's first visits to China and Japan as a young vice-consul stationed in Shanghai. He was twenty-six and still finding his poetic voice. And though his stance in the world is decidedly Christian, the content of this intriguing work reveals an inner dialogue with Buddhist ideas of interconnection, harmony, the ongoing quest for a higher life condition, and the overwhelming impact of nature in the lives of mere humans.In "Pagoda," Claudel describes a seven-story Chinese pagoda as it "amplifies and multiplies the roof, exaggerates the horned corners that rise with an elegant surge, and turns their curves upward to the sky." This form that "does away with walls" and concentrates on the uplifting roof creates a space where "Buddha, Prince of Peace, dwells inside with all the gods." In this architecture he reads a structuring of physical and spiritual space, a kind of never ending upward movement divided into "the seven mystical heavens." The culminating effect is the heavenly achievement of the unknowable. And so, after going as far as he can go into the world of the spirit, he ends this prose poem with an abrupt return to temporal reality. "I have no more to say of the Pagoda. I do not know its name."Elsewhere, in "The Wanderer," he turns his sense of awe toward nature. "Every tree has its personality, every small beast its role, every voice its part in the symphony," he writes. "As one understands music, so I understand nature, like a detailed narrative of proper names; as my walk and the day advance, so does the elaboration of the doctrine." The "doctrine," it seems, is the idea of dependent origination, the interrelation of all life that springs from a single source. In the last line, he states, "I understand the world's harmony. When will I grasp its melody?"In "The Temple of Consciousness" Claudel climbs "the black rock's vertical wall, and only at this late afternoon hour do I know myself to be on the right track." Below, he observes golden rice fields. Ahead there is an "old stairway overlaid with hoary moss... (shrink)

In this paper, we focus on contexts where the primary activity is to expound knowledge about general classes of phenomena, either by categorizing and characterizing them or by explaining them based on some theory, ranging from a commonsense folk theory to an uncommonsense scientific theory. Texts produced in such contexts include science lectures, research articles, and entries in encyclopedias. We focus on explanations, considering them across strata in terms of context, semantics, and lexicogrammar, and summarizing contributions from different research strands. (...) Against this background, we report on a study of the registers used in secondary school chemistry textbooks in Hong Kong. We begin by summarizing a framework for classifying the contexts in which texts operate – a framework designed to allow us to differentiate different kinds of text according to the contexts they operate in. Then, we focus on one type of context – that of expounding knowledge about general classes of phenomena. Next, we identify different strategies of expounding knowledge, contrasting explanations and categorizations, and then discuss explanations in more detail. Finally, we move to the question of how these contextual types are realized semantically as texts organized as rhetorical complexes, drawing on secondary school textbooks in chemistry in particular. (shrink)

Literature for children is often designed to stimulate imagination through variants of the “real” world that we inhabit, expanding their potential for construing different possible worlds – variants that include imaginary characters like animals with human traits or toys that are somehow animated and conscious. Here we will examine one version of Margery William’s classic nursery tale The Velveteen Rabbit, or How Toys Become Real, where the theme of “real” and imaginary characters and worlds is construed both linguistically and pictorially. (...) We will show how the theme is construed in both text and image, and how the two complement one another, together keeping the two worlds apart while at the same time representing the Velveteen Rabbit’s transformation from toy rabbit to real rabbit. (shrink)

As the first large online event of the American Society for Cybernetics, the ASC2020 Global Conversation offered an opportunity to develop new online types of cybernetic conversations on cybernetics, in cybernetic formats. This article discusses the design decisions that led to a particular organizational structure of the event, and observations on how the event unfolded from this organizational structure. Based on observations made throughout the event as well as its preparation stage, the article maps seven different types of conversations taking (...) place before and during the event and discusses opportunities and constraints encountered in relation to each identified type. As online conferences have proliferated exponentially due to the impact of COVID-19, this article aims to contribute a cybernetic perspective to the broader discourse on scholarly international exchange in online media, and offers a new perspective on how such conversations might be designed in a cybernetic manner. (shrink)

The interaction between the concepts of character attachment, agency, and choice in a video game narrative was investigated using BioWare’s Mass Effect trilogy. Posts on a BioWare forum discussing the depiction of their player characters in the ending sequences of Mass Effect 3, the final game in the trilogy, were downloaded and analyzed using thematic analysis. Players demonstrated emotional attachment for the characters and narrative and expected to see the consequences of their choices play out, as in the previous games. (...) Furthermore, players conflated winning the game with achieving a narratively satisfactory ending for the game world and its characters indicating emotional consequences for players that developers should consider when designing games with a high degree of player choice and agency. However, for some players character attachment is incongruous as they described Shepard as “acting out of character,” which needs further research. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews,Shapes oS Philosophical History. By Frank E. Manuel. (Stanford: Stanford University Press, 1965.Pp. 166.$1.95.) Based upon his seven Camp Lectures of 1962 at Stanford, Professor Manuel has issued this taut and recondite volume describing the forms philosophical history has taken in the West. He has performed a difficult task well, giving much scholarly substance to his theme that two archetypal shapes of speculative history-writing have dominated Western thought, (...) one an Augustinian teleological.unitary-procursus view, the other a Polybian, cyclical, Ixionlike, Stoic model. The first is broadly defined as "movement either to a fixed end, or to an indefinite end that defines itself in the course of the progression, history as novelty-creating and always variant"; the second as "circularity, eternal recurrence, return to the beginning of things, sheer reiteration or similar recapitulation." Comte and modem progressists are at the end of the first line, Nietzsehe and Spengler and other cylicists at the end of the second. However, broadly again, amalgamations of the two types are possible, syncretistic variants have often taken shape, and, Protean-hke, both lend themselves to almost infinite interpretive patterns. These typologies are psychological more than logical polarities, both emotional and intellectual alternatives, so they often stand for and serve contradictory purposes. Yet historians tend to betray their preference for one of these opposed conceptions, according to Manuel, as they "select an identity for historic man." Deliberately refraining from taking sides on the issue (thus implicitly casting some doubt on his contention that historians and others "inevitably betray their preference for one of these opposing conceptions"), Manuel addresses himself to the task of illuminating the polarity, exhibiting the multiplicity of its forms through time and focusing upon crucial moments of the debate in the West. Of these exhibits--early Christians vs. pagans, Augustine vs. Joachim, the virtual triumph of cyclicism in the Renaissance (albeit with a split developed between negative and positive, pessimist and optimist cyclicists), the ambivalence of the eighteenth-century Germans on the issue (particularly Kant and Herder), the triumphant optimism of the French perfectibilists, the vacillation of the German academists--Manuel's examination of the French and German writers stands out, although the range of his knowledge and first-hand inspection of archival sources from Augustine's time to Toynbee's demonstrates an admirable scholarship. Of the eighteenth-century Germans, Manuel well illustrates their ambivalent and paradoxical side. Herder, for example, nominally an opponent, debating against "abderite" cyclical theory and apparently concluding in favor of it; Goethe wondering whether the world "will become one great hospital in which we behave toward one another like benign male nurses" if Herder's more optimistic notions triumph; old Kant in his special language rejecting all then current models of world history (moral terrorism, abderitism and eudaemonism ) and opting for what Manuel calls a "mechanism... akin to the cunning of reason" to institute a just civil constitution and estabhsh perpetual peace, yet not really persuaded that his sanguine view of moral progress would prevail. As for the later Germans in and out of the Academy (particularly Hegel, Fichte, Schelling, HSlderlin and Hamann) while youthful enthusiasts of progress (everyone knows the story of the young Hegel and his friends planting the tree of liberty saluting the French revolution), their conceptions of history became more and more Platonic, more and more nostalgic and parochial. On the other hand Manuel's account of the eighteenth and nineteenth-century French relates their boundless energy and dedication to progressist conceptions, a development he holds as quite isolated and isolable from the German movement. Without doubt the French had the most imagination and the most confidence in developing philosophical history to an almost dizzying optimistic pitch. Manuel demonstrates a line from Voltaire through Turgot, Condorcet, Saint-Simon, Fourier and the Saint-Simonians to Auguste Comte, each building on the others in time, each theorizing "man's steady conquest of the external world, beginning in a period when he was still the member of a feeble and isolated band, and culminating in his present high estate." "The Golden Age of the human species is not behind us, it is before [171] 172 HISTORY OF PHILOSOPHY us," Saint-Simon... (shrink)

Our study contributes by providing new insights into the relationship between the individual levels of the antecedents and how the intention of whistleblowing is moderated by perceived organizational support, team norms, and perceived moral intensity. In this paper, we argue that the intention of both internal and external whistleblowing depends on the individual-level antecedents [attitudes toward whistleblowing, perceived behavioral control, independence commitment, personal responsibility for reporting, and personal cost of reporting ] and is moderated by POS, TNs, and PMI. The (...) findings confirm our predictions. Data were collected using an online survey on 256 Indonesian public accountants who worked in the audit firm affiliated with the Big 4 and non-Big 4. The results support the argument that all the antecedents of individual levels can improve the auditors’ intention to blow the whistle. The nature of the relationship is more complex than analysis by adding moderating variables using the Partial Least Squares-Structural Equation Modeling approach. We found that POS, TNs, and PMI can partially improve the relationship between the individual-level antecedents and whistleblowing intentions. These findings indicate that the POS, TNs, and PMI are a mechanism or that attribute is important in controlling behavior. (shrink)

This volume offers an English translation of John of St. Thomas's Cursus theologicus I, question I, disputation 2. In this particular text, the Dominican master raises questions concerning the scientific status and nature of theology. At issue, here, are a number of factors: namely, Christianity's continual coming to terms with the "Third Entry" of Aristotelian thought into Western Christian intellectual culture - specifically the Aristotelian notion of 'science' and sacra doctrina's satisfaction of those requirements - the Thomistic-commentary tradition, and (...) the larger backdrop of the Iberian Peninsula's flourishing "Second Scholasticism." In this latter context, John of St. Thomas applies the theological principles of Thomas Aquinas to the Scholastic disputes preoccupying Thomist, Franciscan, and Jesuit theologians, such as Cajetan, Bañez, Luis de Molina, Vazquez, Suárez - to name only a few - in a tour de force of theological thinking throughout the entire period of Scholasticism. In the process - and not insignificantly - the status quaestionis of theology's scientific character is clearly framed and answered according to John's satisfaction. Key to John of St. Thomas's resolution of the question is his understanding of the continuity of the power of human reason with the super-intelligibility of divine revelation spelled out in terms of what he calls "virtual revelation." This text presented in this volume is a quintessential example of the deep and abiding harmony that flourished between faith and reason as well as grace and nature within the golden era of Baroque Scholasticism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews,Shapes oS Philosophical History. By Frank E. Manuel. (Stanford: Stanford University Press, 1965.Pp. 166.$1.95.) Based upon his seven Camp Lectures of 1962 at Stanford, Professor Manuel has issued this taut and recondite volume describing the forms philosophical history has taken in the West. He has performed a difficult task well, giving much scholarly substance to his theme that two archetypal shapes of speculative history-writing have dominated Western thought, (...) one an Augustinian teleological.unitary-procursus view, the other a Polybian, cyclical, Ixionlike, Stoic model. The first is broadly defined as "movement either to a fixed end, or to an indefinite end that defines itself in the course of the progression, history as novelty-creating and always variant"; the second as "circularity, eternal recurrence, return to the beginning of things, sheer reiteration or similar recapitulation." Comte and modem progressists are at the end of the first line, Nietzsehe and Spengler and other cylicists at the end of the second. However, broadly again, amalgamations of the two types are possible, syncretistic variants have often taken shape, and, Protean-hke, both lend themselves to almost infinite interpretive patterns. These typologies are psychological more than logical polarities, both emotional and intellectual alternatives, so they often stand for and serve contradictory purposes. Yet historians tend to betray their preference for one of these opposed conceptions, according to Manuel, as they "select an identity for historic man." Deliberately refraining from taking sides on the issue (thus implicitly casting some doubt on his contention that historians and others "inevitably betray their preference for one of these opposing conceptions"), Manuel addresses himself to the task of illuminating the polarity, exhibiting the multiplicity of its forms through time and focusing upon crucial moments of the debate in the West. Of these exhibits--early Christians vs. pagans, Augustine vs. Joachim, the virtual triumph of cyclicism in the Renaissance (albeit with a split developed between negative and positive, pessimist and optimist cyclicists), the ambivalence of the eighteenth-century Germans on the issue (particularly Kant and Herder), the triumphant optimism of the French perfectibilists, the vacillation of the German academists--Manuel's examination of the French and German writers stands out, although the range of his knowledge and first-hand inspection of archival sources from Augustine's time to Toynbee's demonstrates an admirable scholarship. Of the eighteenth-century Germans, Manuel well illustrates their ambivalent and paradoxical side. Herder, for example, nominally an opponent, debating against "abderite" cyclical theory and apparently concluding in favor of it; Goethe wondering whether the world "will become one great hospital in which we behave toward one another like benign male nurses" if Herder's more optimistic notions triumph; old Kant in his special language rejecting all then current models of world history (moral terrorism, abderitism and eudaemonism ) and opting for what Manuel calls a "mechanism... akin to the cunning of reason" to institute a just civil constitution and estabhsh perpetual peace, yet not really persuaded that his sanguine view of moral progress would prevail. As for the later Germans in and out of the Academy (particularly Hegel, Fichte, Schelling, HSlderlin and Hamann) while youthful enthusiasts of progress (everyone knows the story of the young Hegel and his friends planting the tree of liberty saluting the French revolution), their conceptions of history became more and more Platonic, more and more nostalgic and parochial. On the other hand Manuel's account of the eighteenth and nineteenth-century French relates their boundless energy and dedication to progressist conceptions, a development he holds as quite isolated and isolable from the German movement. Without doubt the French had the most imagination and the most confidence in developing philosophical history to an almost dizzying optimistic pitch. Manuel demonstrates a line from Voltaire through Turgot, Condorcet, Saint-Simon, Fourier and the Saint-Simonians to Auguste Comte, each building on the others in time, each theorizing "man's steady conquest of the external world, beginning in a period when he was still the member of a feeble and isolated band, and culminating in his present high estate." "The Golden Age of the human species is not behind us, it is before [171] 172 HISTORY OF PHILOSOPHY us," Saint-Simon... (shrink)

Previous research in the visual domain suggests that exogenous attention in form of peripheral cueing increases spatial but lowers temporal resolution. It is unclear whether this effect transfers to other sensory modalities. Here, we tested the effects of exogenous attention on temporal and spectral resolution in the auditory domain. Eighteen young, normal-hearing adults were tested in both gap and frequency change detection tasks with exogenous cuing. Benefits of valid cuing were only present in the gap detection task while costs of (...) invalid cuing were observed in both tasks. Our results suggest that exogenous attention in the auditory system improves temporal resolution without compromising spectral resolution. (shrink)

Background Duty to care is integral to nursing practice. Personal obligations that normally conflict with professional obligations are likely amplified during a public health emergency such as COVID-19. Organizations can facilitate a nurse’s ability to fulfill the duty to care without compromising on personal obligations. Research Aim The study aimed to explore the relationships among duty to care, perception of supportive environment, perceived stress, and COVID-19-specific anxieties in nurses working directly with COVID-19 patients. Research Design The study design was a (...) cross-sectional descriptive study using an online survey. It was conducted at an ANCC Magnet® designated 385-bed acute care teaching hospital located in a suburban area. Participants and Research Context Included in this study were 339 medical surgical nurses working directly with COVID-19 patients during the early phase of the pandemic. Ethical Considerations The study was reviewed by the institution’s clinical research committee and determined to be exempt. A survey invitation letter with a voluntary implied consent agreement was sent to participants with a description of the research study attached to the anonymous survey. Results Nurses with specific COVID-19-related anxieties were more likely to agree that it was ethical to abandon the workplace during a pandemic. Conclusions Organizations can and ought to mitigate the negative effects of COVID-19 on duty to care in future pandemics and healthcare emergencies by incorporating several recommendations derived from this study. (shrink)

The dynamic structure and composition of lipid membranes need to be tightly regulated to control the vast array of cellular processes from cell and organelle morphology to protein‐protein interactions and signal transduction pathways. To maintain membrane integrity, sense‐and‐response systems monitor and adjust membrane lipid composition to the ever‐changing cellular environment, but only a relatively small number of control systems have been described. Here, we explore the emerging role of the ubiquitin‐proteasome system in monitoring and maintaining membrane lipid composition. We focus (...) on the ER‐resident RNF145 E3 ubiquitin ligase, its role in regulating adiponectin receptor 2 (ADIPOR2), its lipid hydrolase substrate, and the broader implications for understanding the homeostatic processes that fine‐tune cellular membrane composition. (shrink)

Design Cybernetics: Navigating the New Design cybernetics offers a way of looking at ourselves – curious, creative, and ethical humans – as self-organising systems that negotiate their own goals in open-ended explorations of the previously unknown. It is a theory of and for epistemic practices that is deeply committed to the autonomy of others and hence offers no prescriptive methodology. Design cybernetics describes design practice as inextricable from conversation – a way of enquiring, developing shared understanding and reaching the new (...) that harnesses reliable control as well as error and serendipity. Recognising circular causality, observer-dependency and non-determinability, design cybernetics extends beyond tenets of scientific research into the creative, ethical and aesthetic domain. From this perspective, design is not an ill-conceived subset of scientific research. Instead, scientific research emerges as a particularly restricted subset of the broader human activity of design. This volume offers a cross-section of design cybernetic theory and practice with contributions ranging across architecture, interior lighting studies, product design, embedded systems, design pedagogy, design theory, social transformation design, research epistemology, art and poetics, as well as theatre and acting. Addressing designers, design educators and researchers interested in a rigorous, practice-based epistemology, it establishes design cybernetics as a foundational perspective of design research. “This is a conceptually elegant, well structured, and comprehensive presentation of design cybernetics. It fills a gap in the literature of the field.” Ken Friedman, Chair Professor, Tongji University “This book offers a valuable and timely introduction to second-order cybernetics as society grapples with complex issues like climate change and rising inequality.” Joichi Ito, Director of the MIT Media Lab. (shrink)

BackgroundTo prevent the planet from catastrophic global warming a reduction of greenhouse gas emissions to net zero is required. Thus, divestment from fossil fuels must be a strategic interest for health insurers. The aim of this study was to analyse the implementation of environmental, social and governance criteria in German private health insurers’ investments.MethodsIn 2019 a survey about ESG strategies was sent to German private health insurance companies. The survey evaluated investment strategies and thresholds for the exclusion of sectors and (...) business practices, as well as company strategies for sustainable business development.FindingsGiven their business reports, German private health insurers manage assets of more than €350 billion. 11 of 40 insurance companies provided quantitative data, 10 refused to answer. According to quantitative data, €66 billion of assets is managed according to any ESG criteria; this equals an average of 76% of each company’s bonds. None of these insurers excluded the production and sale of fossil fuels. All excluded coal mining but only at high thresholds. For €226 billion, no data were provided.InterpretationThe findings are in contrast to the expected intrinsic economic interest of the insurers to stop global warming and improve public health. The majority of assets are managed in a highly problematic manner, especially the absence of capital allocated in fields contrary to medical ethics cannot be presumed. Lack of transparency is a major problem that limits clients in choosing the insurer who has the most advanced ESG criteria. (shrink)

This study examined individual differences in spatial abilities of architecture students. Students at different educational levels were assessed on spatial ability tests that varied in their domain-specificity to architecture, with the hypothesis that larger differences between beginner and advanced students will emerge on more domain-specific tests. We also investigated gender differences in test performance and controlled for general reasoning ability across analyses. In a cross sectional study, master students (N= 91) outperformed beginners (N= 502) on two novel tests involving perspective (...) taking and object composition, as well as on a standardized visualization of cross-sections test, but not on a standardized mental rotations test. Longitudinally (N= 117), spatial performance improved after the first bachelor year on visualization of cross-sections, object composition and mental rotation. Although both genders showed higher spatial test performance with increased experience, male students outperformed females across tests and levels of education. The results overall confirmed improvements in spatial performance during architecture studies, with partial support for the domain-specificity hypothesis. A gender gap among advanced students calls for further examining architecture-specific spatial thinking. (shrink)

The coupling of protein synthesis and folding is a crucial yet poorly understood aspect of cellular protein folding. Over the past few years, it has become possible to experimentally follow and define protein folding on the ribosome, revealing principles that shape co‐translational folding and distinguish it from refolding in solution. Here, we highlight some of these recent findings from biochemical and biophysical studies and their potential significance for cellular protein biogenesis. In particular, we focus on nascent chain interactions with the (...) ribosome, interactions within the nascent protein, modulation of translation elongation rates, and the role of mechanical force that accompanies nascent protein folding. The ability to obtain mechanistic insight in molecular detail has set the stage for exploring the intricate process of nascent protein folding. We believe that the aspects discussed here will be generally important for understanding how protein synthesis and folding are coupled and regulated. (shrink)

Several widely publicized incidents of academic research misconduct, combined with the politicization of the role of science in public health and policy discourse (e.g., COVID, immunizations) threaten to undermine faith in the integrity of empirical research. Researchers often maintain that peer-review and study replication allow the field to self-police and self-correct; however, stark disparities between official reports of academic research misconduct and self-reports of academic researchers, specifically with regard to data fabrication, belie this argument. Further, systemic imperatives in academic settings (...) often incentivize institutional responses that focus on minimizing reputational harm rather than the impact of fabricated data on the integrity of extant and future research. (shrink)

While society debates whether and how to use public funds to support work on human embryonic stem cells (hESCs), many scientific groups and businesses debate a different question — the extent to which patents that cover such stem cells should be permitted to limit or to tax their research. The Wisconsin Alumni Research Foundation (WARF), a non-profit foundation that manages intellectual property generated by researchers at the University of Wisconsin at Madison, owns three patents that have been at the heart (...) of the latter controversy The story of WARF's patents and the controversy they have fostered highlights not only continuing tensions between proprietary and nonproprietary approaches to developing science and technology, but also an at least partly reassuring capacity of public and private sectors to deal with those tensions in a way that can render them substantially manageable, and frequently more manageable as a technology matures. More particularly, the cumulative story of WARF's patents features three leitmotifs that suggest how an attentive and engaged public sector might commonly succeed in working with public and private sector actors to achieve workable balances between proprietary rights and more general social interests: (1) right holders' decisions to pursue less than full rights assertion or enforcement; (2) the ability of government and other public sector actors to help bring about such decisions through co-option or pressure; and (3) the frequent availability or development of technological alternatives that limit research bottlenecks. (shrink)

While society debates whether and how to use public funds to support work on human embryonic stem cells, many scientific groups and businesses debate a different question — the extent to which patents that cover such stem cells should be permitted to limit or to tax their research. The Wisconsin Alumni Research Foundation, a non-profit foundation that manages intellectual property generated by researchers at the University of Wisconsin at Madison, owns three patents that have been at the heart of the (...) latter controversy. The story of WARF’s patents and the controversy they have fostered highlights not only continuing tensions between proprietary and nonproprietary approaches to developing science and technology, but also an at least partly reassuring capacity of public and private sectors to deal with those tensions in a way that can render them substantially manageable, and frequently more manageable as a technology matures. (shrink)

A fundamental problem with the Clark & Thornton definition of a type-1 problem (requirement 2) is identified. An alternative classical statistical formulation is proposed where a type-1 (learnable) problem corresponds to the case where the learning machine is capable of representing its statistical environment.

A neurally plausible model of how the process of visually perceiving a letter in the context of a word is learned, and how such processing occurs in adults is proposed. The model consists of a collection of abstract letter feature detector neurons and their interconnections. The model also includes a learning rule that specifies how these interconnections evolve with experience. The interconnections between neurons can be interpreted as representing the spatially redundant, sequentially redundant, and transgraphemic information in letter string displays. (...) Anderson, Silverstein, Ritz, and Jones's (1977) “Brain‐State‐in‐a‐Box” (BSB) neural mechanism is then used to implement the proposed model. The resulting system makes explicit qualitative predictions using both letter recognition accuracy and reaction time as dependent measures. In particular, the model offers an integrated explanation of some experiments involving manipulations of orthographic regularity, masking, case alternations, and experience with words. The similarities and differences between the model and models proposed by Adams (1979) and McClelland and Rumelhart (1981) are also discussed. (shrink)

The notion of a “familiar example” used in Page's definition of a “localist model” is shown to be meaningful only with respect to the types of tasks faced by the connectionist model. It is also shown that the modeling task ultimately dictates which choice of model: “localist” or “distributed” is most appropriate.

Research in the organizational sciences has tended to portray prosocial behavior as an unqualified positive outcome that should be encouraged in organizations. However, only recently, have researchers begun to acknowledge prosocial behaviors that help maintain an organization’s positive image in ways that violate ethical norms. Recent scandals, including Volkswagen’s emissions scandal and Penn State’s child sex abuse scandal, point to the need for research on the individual factors and situational conditions that shape the emergence of these unethical pro-organizational behaviors. Drawing (...) on trait activation theory, we argue that the “dark” trait of Machiavellianism should make individuals more willing to engage in UPB. Further, we argue that this willingness will be augmented when Machiavellians hold bottom-line-mentality climate perceptions, or the perception that ethical standards matter less than organizational performance. Using data from 170 U.S. employees, results suggested that Machiavellians are more willing to engage in UPB, but that BLMCPs may not affect their motivation to engage in UPB. We discuss the study’s theoretical and practical implications, as well as avenues for research. (shrink)

Emotion theorists have long held that a fundamental characteristic of an emotion is how its constituent processes change and interact over time. Assessing these temporal dynamics of emotion in the brain is critical for understanding the neural representation of emotions as well as advancing theories of emotional processing. We review the neuroimaging research on three temporal dynamic features of emotion: time of onset, duration, and resurgence and show how assessing these temporal dynamics in the brain have led to improved understanding (...) of the structure and function of emotional processes such as revealing which appraisals come first, how emotional processing endures both explicitly and implicitly, and that the resurgence of emotional processing may consist of either single or multiple processes. (shrink)